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KMID : 0882420140860060774
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Korean Journal of Medicine
2014 Volume.86 No. 6 p.774 ~ p.780
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Hodgkin’s Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma
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Park Soo-Youn
Yu Hyung-Min
Kim Ji-Wan
An Sang-Hee
Kim Wook-Youn
Hur Mi-Na
Lee Hong-Gi
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Abstract
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Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin’s lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.
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KEYWORD
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Lymphoproliferative disorder, Hodgkin disease, Hematopoietic stem cell transplantation, Epstein-Barr virus
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